Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. 1. "New once-daily HIV combination better tolerated." In an asymptomatic HIV infection study, anorexia was reported in 19.3% (using 1500 mg) and 20.1% (using 500 mg) of patients using zidovudine. Incidence was higher in patients with mild laboratory abnormalities at baseline. muscle cramps, pain, stiffness, or spasms, pains in the stomach, side, or abdomen, possibly radiating to the back, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, right upper abdominal or stomach pain and fullness, burning, tingling, numbness or pain in the hands, arms, feet, or legs, weight gain around your neck, upper back, breast, face, or waist. Tell your doctor if … Copyright © 2021 IBM Watson Health. Gallant JE, DeJesus E, Arribas JR, et al "Tenofovir DF, emtricitabine, and efavirenz vs. zidovudine, lamivudine, and efavirenz for HIV." These serious side effects may occur more often in women and obese patients. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. [Ref], In an advanced HIV disease study, vasodilation was reported in less than 5% of patients using zidovudine. This content does not have an Arabic version. This site complies with the HONcode standard for trustworthy health information: verify here. All rights reserved. Ann Intern Med 117 (1992): 487-501, 20. Portions of this document last updated: Feb. 01, 2021. Common Questions and Answers about Lamivudine side effects. It may be used in people with both HIV and tuberculosis, however if the person is on rifampicin a larger dose of dolutegravir is needed.. Side effects. Med J Aust 150 (1989): 339-40, 19. J Am Acad Dermatol 21 (1989): 192-3, 27. Some side effects may not be reported. These side effects may go away during treatment as your body adjusts to the medicine. Data sources include IBM Watson Micromedex (updated 3 Mar 2021), Cerner Multum™ (updated 1 Mar 2021), ASHP (updated 3 Mar 2021) and others. In this study, chills, influenza syndrome, and chest pain were reported in less than 5% of patients using zidovudine. Taking efavirenz, lamivudine, and tenofovir at bedtime may make certain side effects less bothersome. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Description: Lamivudine, a synthetic nucleoside analogue, is phosphorylated into the body to the active 5'-triphosphate metabolite.It inhibits RNA- and DNA-dependent polymerase activities of reverse transcriptase via DNA chain termination. Piacenti FJ "An update and review of antiretroviral therapy." Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. It is either used by itself or along with other antiretrovirals. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. All rights reserved. Side effects and tolerability of post-exposure prophylaxis with zidovudine, lamivudine, and lopinavir/ritonavir: a comparative study with HIV/AIDS patients Chin Med J (Engl). 7. Rabaud C, Burty C, Grandidier M, et al. Tell your doctor if you have: signs of a new infection --fever, night sweats, swollen glands, cold sores, cough, wheezing, diarrhea, weight loss; Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer — Mayo Clinic Health Letter, Time running out - 40% off Online Mayo Clinic Diet ends soon. It is much better tolerated than interferon. Severe acute exacerbations of hepatitis have been reported in patients with hepatitis B after discontinuation of lamivudine. Many people using this medication do not have serious side effects. Pavel S, Burty C, Alcaraz I, et al. These hematological effects were generally observed after 4 to 6 weeks of therapy. In an advanced HIV disease study, headache (42%), somnolence (8%), dizziness (6%), paresthesia (6%), and taste perversion (5%) were reported with zidovudine; only headache was reported at a significantly greater rate than placebo. Medical uses. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to lamivudine / zidovudine: oral tablet, Side effects have been reported with lamivudine and zidovudine, administered separately or together. Zidovudine has been associated with hematologic toxicity (including neutropenia and severe anemia), particularly in patients with advanced HIV-1 disease. Take efavirenz, lamivudine, and tenofovir exactly as directed. In this study, acne, pruritus, urticaria, nail pigmentation, and body odor were reported in less than 5% of patients using zidovudine. These side effects may go away during treatment as your body adjusts to the medicine. In this study, redistribution/accumulation of body fat was reported in less than 5% of patients using zidovudine. Serious side effects and their symptoms can include the following: Lactic acidosis or severe liver enlargement. pains in the stomach, side, or abdomen, possibly radiating to the back pinpoint red spots on the skin puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue right upper abdominal or stomach pain and fullness Gastro-intestinal disorders: Pancreatitis, upper abdominal pain, … "Product Information. Advertising revenue supports our not-for-profit mission. In the early symptomatic HIV disease study, nausea (61%), vomiting (25%), and dyspepsia (6%) were reported with zidovudine. Available from: URL: https://aidsinfo.nih.gov/contentfiles/lvguidelines/adultandadolescentgl.pdf." 9. Some side effects may occur that usually do not need medical attention. Cerner Multum, Inc. "UK Summary of Product Characteristics." Lamivudine/nevirapine/stavudine (3TC/NVP/d4T) is a fixed-dose combination antiretroviral medication used to treat HIV/AIDS. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Mayo Clinic does not endorse companies or products. Aids 14 (2000): 1309-16, 13. Side effects have been reported with lamivudine and zidovudine, administered separately or together. Am J Med 86 (1989): 814-8, 15. Dubin G, Braffman MN "Zidovudine-induced hepatotoxicity." Call your doctor for medical advice about side effects. Panel on Antiretroviral Guidelines for Adults and Adolescents "Guidelines for the use of antiretroviral A rare and potentially fatal condition called lactic acidosis can develop in patients taking lamivudine. Mayo Clinic facts about coronavirus disease 2019 (COVID-19), Our COVID-19 patient and visitor guidelines, plus trusted health information, Mayo Clinic Health System patient vaccination updates. Headache, dizziness, nausea, diarrhea, or trouble sleeping may occur. AIDS 17 (2003): 1988-90, 23. Dose reduction has not affected the course of myopathy, although drug discontinuation sometimes resulted in improvement of symptoms, generally within a month. In fact, in at least one trial, the lamivudine had fewer side effects than the placebo pills. Drug information provided by: IBM Micromedex. O'Dowd MA, McKegney FP "Manic syndrome associated with zidovudine." Glaxo Wellcome, Research Triangle Park, NC. Lamivudine (3tc) (Epivir; Epivir HBV) is a drug prescribed for the treatment of HIV infection and hepatitis B infection. Do not take more or less of it or take it more often than prescribed by your doctor. O 0, 4. McLeod GX, Hammer SM "Zidovudine: five years later." In an advanced HIV disease study, rash (17%) and diaphoresis (5%) were reported with zidovudine. In the early symptomatic HIV disease study, asthenia was reported in 69% of patients using zidovudine. Wright JM, Sachdev PS, Perkins RJ, Rodriguez P "Zidovudine-related mania." In an advanced HIV disease study, myalgia (8%) was reported with zidovudine at a significantly greater rate than placebo. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. In an advanced HIV disease study, nausea (46%), GI pain (20%), diarrhea (12%), vomiting (6%), and dyspepsia (5%) were reported with zidovudine; only nausea was reported at a significantly greater rate than placebo. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. hypertriglyceridaemia, hypercholesterolaemia, insulin resistance, hyperglycaemia, hyperlactataemia), osteonecrosis; … Lamivudine side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. The most serious side include muscle pain, liver failure, pancreatitis, and liver failure. Am J Med 86 (1989): 469-70, 26. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. [Ref], Common (1% to 10%): Elevated ALT, elevated AST, abnormal liver function tests, Uncommon (0.1% to 1%): Elevated bilirubin, Frequency not reported: Severe hepatomegaly with steatosis, hepatic decompensation, Postmarketing reports: Hepatic steatosis, posttreatment exacerbation of hepatitis B, -Uncommon (0.1% to 1%): Elevated liver enzymes (AST, ALT), -Rare (0.01% to 0.1%): Hepatitis, abnormal liver function tests, -Common (1% to 10%): Elevated liver enzyme levels in blood (including ALT, AST), elevated bilirubin levels in blood, -Rare (0.01% to 0.1%): Liver disorders (e.g., severe hepatomegaly with steatosis), -Frequency not reported: Changes in liver function tests (including increased AST levels), acute hepatic failure[Ref], Common (1% to 10%): Neutropenia, anemia, lymphatic signs/symptoms, decreased white cells, Postmarketing reports: Anemia (including pure red cell aplasia and anemias progressing on therapy), lymphadenopathy, splenomegaly, -Uncommon (0.1% to 1%): Neutropenia, anemia, thrombocytopenia, decreased white cells, -Very rare (less than 0.01%): Pure red cell aplasia, -Very common (10% or more): Granulocytopenia, anemia, -Common (1% to 10%): Neutropenia, leukopenia, lymphatic signs/symptoms, decreased white cells, thrombocytopenia, -Uncommon (0.1% to 1%): Pancytopenia (with marrow hypoplasia), -Rare (0.01% to 0.1%): Pure red cell aplasia, -Very rare (less than 0.01%): Aplastic anemia, -Frequency not reported: Exacerbation of anemia, hemolytic anemia, hematologic toxicity (including neutropenia, severe anemia), lymphadenopathy[Ref]. Neutropenia (absolute neutrophil count less than 750/mm3), anemia (hemoglobin less than 8 g/dL), and thrombocytopenia (platelets less than 50,000/mm3) have been reported in 7.2%, 2.9%, and 0.4% of patients using lamivudine plus zidovudine, respectively, and 5.4%, 1.8%, and 1.3% of patients using zidovudine, respectively. In this study, anxiety, confusion, depression, emotional lability, nervousness, and loss of mental acuity were reported in less than 5% of patients using zidovudine. Lamivudine Side Effects See also Warning section. Our general interest e-newsletter keeps you up to date on a wide variety of health topics.